3-Amino-4-pyrazole carbosamide hemisulfate

ʻO ka waena no ka synthesis o allopurinol.

ʻO ia kekahi o ka 3-amino-4-substituted pyrazole series.Hiki ke hoʻohana ʻia ma ke ʻano he mea waena e synthesize i nā mea hoʻohui lāʻau lapaʻau maikaʻi loa, e like me allopurinol, kekahi o ka pyrazolopyrimidine derivatives series, ka mea hope mai 1963 Mai kona hoʻohana ʻana i ka lāʻau lapaʻau, ʻo ia ka lāʻau nui no ka mālama ʻana i ka gout.I kēia manawa, liʻiliʻi nā ala i ʻike ʻia no ka synthesizing

ʻO ka 3-aminopyrazole-4-carboxamide hemisulfate ma Kina, ma ka hana ʻana i ka malononitrile a me ka triethyl orthoformate e hoʻomākaukau ai i ka ethoxymethylene malononitrile, a laila me ka hopena o ka hydrazine hydrate e hāʻawi mai i ka 3-amino-4-cyanopyrazole, ka mea i hoʻopau hope ʻia me ka acidic concentrated.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis o 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), ka huina o ka hua o ʻO ka synthesis ma kēia ala e pili ana i 60% (helu ʻia e like me ka malononitrile), ʻo kēia ʻano hana ʻekolu mau ʻanuʻu, ʻoi aku ka lōʻihi o nā ʻanuʻu, a ʻo nā reagents i hoʻohana ʻia, e like me malononitrile a me ethoxymethylene malononitrile, ʻoi aku ka ʻona a me ke kumukūʻai.Eia kekahi,ʻo ka 3-aminopyrazole-4 i hoʻomākaukauʻia e kēiaʻano -Formamide hemisulfate he kala paʻakikī e wehe a koi aku i ka hana hou,ʻoi aku ka paʻakikī.

Aia nā hōʻike ma nā palapala haole e hoʻohana ana i ka pyridylamide hydrazone a me ka ethoxymethylene malononitrile ma ke ʻano he kumu waiwai e loaʻa ai ka 3-amino-4-cyanopyrazole ma o ka hoʻohui ʻana a me ka cyclization, a laila e hana me ka sulfuric acid concentrated e loaʻa ai ka pūhui pahuhopu (Reuken G Jones. Reactions of orthoesters with pūhui activemethylene[J] J Am Chem Soc. 1952,74(5) :4889 4891).ʻO nā kumu waiwai nui i hoʻohana ʻia i kēia ʻano he kumukūʻai, ʻaʻole kiʻekiʻe ka hopena o ka hopena, a haʻahaʻa ka loaʻa kālā o ka hana ʻoihana.Paʻakikī paha.