2-butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylaMino)propoxy]phenyl]

Hoʻohana ʻia ia i nā mea maʻi me ka hyperuricemia mua a me ka lua, ʻoi aku hoʻi i nā mea maʻi me ka hyperuricemia, a me nā mea maʻi me ka renal insufficiency, a me nā mea maʻi me ka gout recurrent a maʻi, a me nā mea maʻi me Hyperuricemia.Hoʻohana ʻia i nā poʻe maʻi me ka nephropathy ʻo Gouty e hōʻoluʻolu i nā hōʻailona a hōʻemi i ka hoʻokumu ʻana o nā pōhaku uric acid renal;nā pōhaku gout;hoʻohana ʻia i nā pōhaku uric acid a me ka maʻi uric acid.

ʻO ka lāʻau anti-arrhythmic hou ʻo Atrial fibrillation (AF) kahi maʻi weliweli i ke ola.Ma muli o ka ʻelemakule o ka heluna kanaka, ke piʻi nei ka ulu ʻana o ka honua a me ka make ʻana o ka fibrillation atrial, a ua lilo ia i pilikia olakino hou.Aia he 2.5 miliona mau maʻi me ka fibrillation atrial ma ʻAmelika Hui Pū ʻIa a me 4.5 miliona ma ka European Union.Wahi a nā helu helu, ʻo ka prevalence o ka atrial fibrillation ma waena o nā poʻe ma mua o 30 mau makahiki ma koʻu ʻāina he 0.77%, e piʻi ana me ka makahiki, a ʻoi aku ka kiʻekiʻe o nā kāne ma mua o nā wahine (0.9%:0.7%).ʻO nā maʻi e hoʻoulu ai i ka fibrillation atrial ka nui o ka hypertension, ka maʻi naʻau coronary, ka maʻi puʻuwai valvular, ka cardiomyopathy ākea ākea, a me ka pau ʻole o ka naʻau.ʻO ka hōʻailona nui o ka poʻe maʻi me ka atrial fibrillation he irregular ventricular rate, a noho ka mana o ka puʻuwai i kahi kūlana i ka mālama ʻana a me ka mālama ʻana i nā hōʻailona.He kuleana maikaʻi ʻo Amiodarone i ka hoʻomalu ʻana i ka puʻuwai a me ka hoʻihoʻi ʻana i ke kani o ka sinus, akā ʻo nā hopena ʻino o nā kino i hoʻopaʻa ʻia e pili ana i ka ʻāpana iodine i loko o kona ʻano e hoʻopaʻa i kāna noi lapaʻau, e like me ka hōʻino ʻana i ka māmā, thyroid, a me ka ate.ʻO nā hopena ʻino i ʻōlelo ʻia ma luna a me kona ʻano ʻO ka iodine i pili pili loa.Ua loaʻa ka lāʻau antiarrhythmic hou Dronedarone (Dronedarone) ma ka hoʻololi ʻana i ke ʻano o amiodarone.Loaʻa iā Dronedarone nā waiwai electrophysiological e like me amiodarone, akā ʻaʻole i loko o ka iodine i loko o kona ʻano, no laila hiki iā ia ke pale i nā hopena koʻikoʻi extra-cardiac i hoʻokumu ʻia e ka iodine Chemicalbook.Ua'āponoʻiaʻo Dronedarone no ka kūʻaiʻana e ka US Food and Drug Administration (FDA) i Iulai 2009, a ua'āponoʻia no ka kūʻaiʻana ma ka European Union ma 2009. ʻO ia hoʻi ka lāʻau antiarrhythmic hou mua i'āponoʻia ma ka European Union i nā makahiki 10.ʻO Dronedarone ka N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]phenyl]-5-benzofuranyl]-methanesulfonamide, ʻo ia ka mea e hōʻemi ai i kahi derivative benzofuran i loaʻa ma ka hoʻololi ʻana o ka amiodarone, ʻaʻole ia he hopena ʻino o ka naʻau.Wehe ia i ka iodine atom ma amiodarone e hoʻemi i ka ʻawaʻawa o ka thyroid a me nā mea ʻē aʻe;hoʻohui i kahi hui methylsulfonyl ma ka ʻaoʻao benzofuran e hōʻemi i ka lipophilicity, ma laila e hoʻopōkole ai i ka hapalua o ke ola o ka lāʻau lapaʻau a hōʻemi i ka hopena o ka hōʻiliʻili ʻana a me ka hiki o ka lāʻau O neurotoxicity.ʻO ka 2011 US version a me ka 2010 European version of the Atrial Fibrillation Guidelines e paipai i ka dronedarone no ka mālama ʻana i ka fibrillation atrial.He palekana a maikaʻi ʻo Dronedarone i ka mālama ʻana i ka rate ventricular a me ka mālama ʻana i ka nui o ka sinus i nā maʻi like ʻole me ka AF koʻikoʻi.Hiki ke lilo i lāʻau lapaʻau kūpono e pani ai i ka amiodarone.Hiki iā Dronedarone ke hoʻemi i ka make o nā maʻi AF a me nā maʻi AF hoʻomau.No laila, manaʻo ʻia e lilo ia i lāʻau lapaʻau mua no ka poʻe maʻi AF me ka ʻole o ka puʻuwai koʻikoʻi.Eia kekahi, ʻoi aku ka maikaʻi o ka hoʻohana ʻana i nā anticoagulants i nā maʻi AF waena-kiʻekiʻe i ka hoʻohana ʻana i ka dronedarone.