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2-butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylaMino)propoxy]phenyl]

2-butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylaMino)propoxy]phenyl]

ʻO ka wehewehe pōkole:

Kumu molekala: C30H40N2O5

Kaumaha molekula: 508.65

CASno: 141645-23-0


Huahana Huahana

Huahana Huahana

Palapala noi

Hoʻohana ʻia ia i nā mea maʻi me ka hyperuricemia mua a me ka lua, ʻoi aku hoʻi i nā mea maʻi me ka hyperuricemia, a me nā mea maʻi me ka renal insufficiency, a me nā mea maʻi me ka gout recurrent a maʻi, a me nā mea maʻi me Hyperuricemia.Hoʻohana ʻia i nā poʻe maʻi me ka nephropathy ʻo Gouty e hōʻoluʻolu i nā hōʻailona a hōʻemi i ka hoʻokumu ʻana o nā pōhaku uric acid renal;nā pōhaku gout;hoʻohana ʻia i nā pōhaku uric acid a me ka maʻi uric acid.

ʻO ka lāʻau anti-arrhythmic hou ʻo Atrial fibrillation (AF) kahi maʻi weliweli i ke ola.Ma muli o ka ʻelemakule o ka heluna kanaka, ke piʻi nei ka ulu ʻana o ka honua a me ka make ʻana o ka fibrillation atrial, a ua lilo ia i pilikia olakino hou.Aia he 2.5 miliona mau maʻi me ka fibrillation atrial ma ʻAmelika Hui Pū ʻIa a me 4.5 miliona ma ka European Union.Wahi a nā helu helu, ʻo ka prevalence o ka atrial fibrillation ma waena o nā poʻe ma mua o 30 mau makahiki ma koʻu ʻāina he 0.77%, e piʻi ana me ka makahiki, a ʻoi aku ka kiʻekiʻe o nā kāne ma mua o nā wahine (0.9%:0.7%).ʻO nā maʻi e hoʻoulu ai i ka fibrillation atrial ka nui o ka hypertension, ka maʻi naʻau coronary, ka maʻi puʻuwai valvular, ka cardiomyopathy ākea ākea, a me ka pau ʻole o ka naʻau.ʻO ka hōʻailona nui o ka poʻe maʻi me ka atrial fibrillation he irregular ventricular rate, a noho ka mana o ka puʻuwai i kahi kūlana i ka mālama ʻana a me ka mālama ʻana i nā hōʻailona.He kuleana maikaʻi ʻo Amiodarone i ka hoʻomalu ʻana i ka puʻuwai a me ka hoʻihoʻi ʻana i ke kani o ka sinus, akā ʻo nā hopena ʻino o nā kino i hoʻopaʻa ʻia e pili ana i ka ʻāpana iodine i loko o kona ʻano e hoʻopaʻa i kāna noi lapaʻau, e like me ka hōʻino ʻana i ka māmā, thyroid, a me ka ate.ʻO nā hopena ʻino i ʻōlelo ʻia ma luna a me kona ʻano ʻO ka iodine i pili pili loa.Ua loaʻa ka lāʻau antiarrhythmic hou Dronedarone (Dronedarone) ma ka hoʻololi ʻana i ke ʻano o amiodarone.Loaʻa iā Dronedarone nā waiwai electrophysiological e like me amiodarone, akā ʻaʻole i loko o ka iodine i loko o kona ʻano, no laila hiki iā ia ke pale i nā hopena koʻikoʻi extra-cardiac i hoʻokumu ʻia e ka iodine Chemicalbook.Ua'āponoʻiaʻo Dronedarone no ka kūʻaiʻana e ka US Food and Drug Administration (FDA) i Iulai 2009, a ua'āponoʻia no ka kūʻaiʻana ma ka European Union ma 2009. ʻO ia hoʻi ka lāʻau antiarrhythmic hou mua i'āponoʻia ma ka European Union i nā makahiki 10.ʻO Dronedarone ka N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]phenyl]-5-benzofuranyl]-methanesulfonamide, ʻo ia ka mea e hōʻemi ai i kahi derivative benzofuran i loaʻa ma ka hoʻololi ʻana o ka amiodarone, ʻaʻole ia he hopena ʻino o ka naʻau.Wehe ia i ka iodine atom ma amiodarone e hoʻemi i ka ʻawaʻawa o ka thyroid a me nā mea ʻē aʻe;hoʻohui i kahi hui methylsulfonyl ma ka ʻaoʻao benzofuran e hōʻemi i ka lipophilicity, ma laila e hoʻopōkole ai i ka hapalua o ke ola o ka lāʻau lapaʻau a hōʻemi i ka hopena o ka hōʻiliʻili ʻana a me ka hiki o ka lāʻau O neurotoxicity.ʻO ka 2011 US version a me ka 2010 European version of the Atrial Fibrillation Guidelines e paipai i ka dronedarone no ka mālama ʻana i ka fibrillation atrial.He palekana a maikaʻi ʻo Dronedarone i ka mālama ʻana i ka rate ventricular a me ka mālama ʻana i ka nui o ka sinus i nā maʻi like ʻole me ka AF koʻikoʻi.Hiki ke lilo i lāʻau lapaʻau kūpono e pani ai i ka amiodarone.Hiki iā Dronedarone ke hoʻemi i ka make o nā maʻi AF a me nā maʻi AF hoʻomau.No laila, manaʻo ʻia e lilo ia i lāʻau lapaʻau mua no ka poʻe maʻi AF me ka ʻole o ka puʻuwai koʻikoʻi.Eia kekahi, ʻoi aku ka maikaʻi o ka hoʻohana ʻana i nā anticoagulants i nā maʻi AF waena-kiʻekiʻe i ka hoʻohana ʻana i ka dronedarone.

E hoʻohana:Kūwaena no Dronedarone hydrochloride
Kūlana:kūlana ʻoihana
ʻIke:≥98%

waho:Wai ʻaila melemele
Pūʻolo:25kg / pahu

Laina Huahana hoʻohui waiwai

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Palapala

Ua loaʻa iā JIN DUN MedicalʻO ka hōʻailona ISO a hoʻokō i nā kūlana hana GMP, hoʻohana i nā loea hoʻolaʻa lāʻau kūloko a me nā haole me ka ʻike waiwai e alakaʻi i ka R&D o ka hui.

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Nā Pōmaikaʻi ma ka Hoʻoponopono Lapaʻau

NA POMAIKAI ANA IA
●Kiʻekiʻe Pressure Catalytic Hydrogenation.ʻO ke kiʻekiʻe o ka Hydrogenolysis Reaction.Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
● Hoʻoponopono hou
●Chiral Resolution
●Heck, Suzuki, Negishi, Sonogashira .Pane ʻo Gignard

JIN DUN R&D

Mea lako

Loaʻa i kā mākou Lab nā mea hoʻokolohua like ʻole, e like me: NMR (Bruker 400M) 、HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000)、IR, UV, GC, GC-MS, Chromatography, ʻO ka Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...

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He pūʻulu o nā limahana R&D ʻoihana ʻo Jindun Medical, a hoʻohana i nā loea synthesis lāʻau kūloko a me nā ʻāina ʻē e alakaʻi i ka R&D, e ʻoi aku ka pololei a me ka maikaʻi o kā mākou synthesis.

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Kaʻana like

Ua kōkua mākou i kekahi mau ʻoihana lapaʻau kūloko kiʻekiʻe, e like meHansoh, Hengrui a me HEC Pharm.Maanei e hōʻike mākou i kahi hapa o lākou.

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Hana Hana Hoʻokahi:

Ka helu helu: 110351-94-5

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Hana Hana Hana ʻelua:

Ka helu helu: 144848-24-8

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Hana Hoʻoponopono ʻEkolu:

Ka helu helu: 200636-54-0

ʻAno hana like

1.Hoʻopilikino i nā mea waena hou a i ʻole API.E like me ka mea ma luna o ka hihia kaʻana like, nā mea kūʻai aku i nā koi no nā Intermediates kūikawā a i ʻole API, a ʻaʻole hiki iā lākou ke ʻike i nā huahana e pono ai i ka mākeke, a laila hiki iā mākou ke kōkua iā Customize.

2.Hoʻoponopono Kaʻina no nā Huahana Kahiko.E kōkua kā mākou hui i ka Optimize a hoʻomaikaʻi i ka hana ʻana i ke ala ʻoi aku ka wā kahiko, kiʻekiʻe ke kumu kūʻai, a haʻahaʻa ka hana.Hiki iā mākou ke hāʻawi i nā palapala piha no ka hoʻololi ʻenehana a me ka hoʻomaikaʻi ʻana i ke kaʻina hana, kōkua i ka mea kūʻai aku no ka hana ʻoi aku ka maikaʻi.

Mai nā pahuhopu lāʻau i nā IND, hāʻawi ʻo JIN DUN Medical iā ʻoenā hoʻonā R&D pilikino hoʻokahi.

Ke koi nei ʻo JIN DUN Medical i ka hoʻokumu ʻana i kahi hui me nā moeʻuhane, hana i nā huahana hanohano, meticulous, rigorous, a hele i nā mea a pau e lilo i hoa hilinaʻi a me ka hoaaloha o nā mea kūʻai aku!


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