5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2 (4h)-one

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2 (4h)-hoʻohana ʻia ma ke ʻano he waena o Prasugrel .
ʻO Prasugrel kahi antiplatelet thiophenopyridine i hoʻomohala ʻia e Eli Lilly a me daiichisankyo, kahi mea hana lāʻau lapaʻau Iapana.He lāʻau mua ia.Hoʻokumu ia i ka molekele ikaika ma hope o ka metabolism ma o ka cytochrome P450 i loko o ke ake a hui pū me ka platelet P2Y12 receptor e hoʻoikaika ikaika e kūʻē i ka platelet aggregation.Ua hōʻike ʻia nā noiʻi maʻi maʻi he 60 mg ka hopena anticoagulant ʻoi aku ka maikaʻi ma mua o 300 mg maʻamau maʻamau a me 600 mg ka nui o ka clopidogrel, hiki ke hōʻemi i ka hopena o ka hōʻeha puʻuwai, ka hahau a me ka make ma muli o ka maʻi puʻuwai e 20%, a he hopena wikiwiki. , maikaʻi curative hopena, maikaʻi lāʻau kū'ē a me ka bioavailability, a haʻahaʻa toxicity.