ʻO ke kahua o ka hoʻokō ʻana i nā moeʻuhane o kā mākou limahana!No ke kūkulu ʻana i kahi hui hauʻoli, hui pū a ʻoi aku ka ʻoihana!No ka loaʻa ʻana o ka uku like ʻole o kā mākou mea kūʻai, nā mea hoʻolako, ka hui a me mākou iho no ka MOQ haʻahaʻa no ke kūʻai wela!ʻO ka Hale Hana Mea Kiʻekiʻe Betrixaban Raw Materials CAS 330942-05-7, Heʻoiaʻiʻo mākou a wehe.Ke nānā nei mākou i mua o ka hoʻomaha ʻana a hoʻonohonoho i ka pilina pili pono a lōʻihi.
ʻO ke kahua o ka hoʻokō ʻana i nā moeʻuhane o kā mākou limahana!No ke kūkulu ʻana i kahi hui hauʻoli, hui pū a ʻoi aku ka ʻoihana!No ka loaʻa ʻana o ka uku like ʻole o kā mākou mea kūʻai, nā mea hoʻolako, ka hui a me mākou iho noKina Lapaʻau Kūwaena a me 330942-05-7, "ʻO ka maikaʻi maikaʻi a me ke kumukūʻai kūpono"ʻo kā mākou mau kumuhanaʻoihana.Inā makemake ʻoe i kā mākou hāʻina a i ʻole he nīnau, e hoʻomanaʻo e hoʻokaʻaʻike mai iā mākou.Manaʻolana mākou e hoʻokumu i nā pilina pili me ʻoe i ka wā e hiki mai ana.
Ka Hana Ola Ola Fondaparinux
E wehewehe | ʻO ka sodium Fondaparinux kahi mea hoʻopaneʻe antithrombin-dependent factor Xa. |
PiliMāhele | ala hōʻailona >> Metabolic enzymes/proteases >> Factor Xa Research areas >> Cardiovascular maʻi |
Kuhikuhi | Kumu Xa[1] |
In vitronā haʻawina | ʻO Fondaparinux sodium ka anticoagulant hou mua e koho pono ana i ka mea Xa.No Fondaparinux, he 0.59±0.05 ka waiwai IC50 (anti-Xa IU/ml) o nā monocytes i ho'ā 'ia (ac-M), a he 0.17±0.03 ka monocyte-derived particles (MMP) [2]. |
I loko o vivonoiʻi | Loaʻa i ka Fondaparinux sodium kahi laina pharmacokinetic profile, pili i ka dosis, e hāʻawi ana i kahi pane hiki ke wānana.Loaʻa ka sodium Fondaparinux i ka 100% bioavailability, he wikiwiki ka hoʻomaka ʻana o ka hana, loaʻa ka hapalua o ke ola o 14 a 16 mau hola, a hiki ke hoʻomau i ka pale ʻana i ka thrombosis i loko o 24 mau hola.ʻAʻole pili ka lāʻau lapaʻau i ka manawa prothrombin a i ʻole ka manawa o ka thromboplastin partial, ʻaʻole ia e pili i ka hana platelet a i ʻole ka hōʻuluʻulu ʻana [1]. |
Nā kuhikuhi | [1].Bauer KA.et al.ʻO ka sodium Fondaparinux: kahi mea hoʻokae koho o ka mea Xa.Am J Health Syst Pharm.2001 Nov 1;58 Suppl 2:S14-7.[2].Ben-Hadj-Khalifa S, et al.ʻO ka hopena pale coagulation ʻokoʻa o ka fondaparinux, enoxaparin a me ka heparin unfractionated i nā hiʻohiʻona cell o ka hanauna thrombin.Koko Coagul Fibrinolysis.2011 Iulai;22(5):369-73. |
Nā waiwai kino a me ke kino o Fondaparinux
ʻAno molekala | C31H53N3Na10O49S8 |
Kaumaha molekula | 1738.16 |
PSA | 900.82000 |
ʻO Fondaparinux kahi ʻano lāʻau antithrombotic hou i ʻae ʻia e ka FDA ma hope o ka heparin a me ka haʻahaʻa molecular weight heparin no ka mālama ʻana a me ka pale ʻana i nā ʻano arteriovenous thrombosis.
Nā hōʻailona: Hoʻohana ʻia ʻo Fondaparinux no nā poʻe maʻi e hana ana i nā ʻokiʻoki orthopedic nui o nā lālā haʻahaʻa, e like me ka haʻi ʻana o ka ʻūhā, ka ʻoki kuli nui a i ʻole ke pani ʻana i ka ʻūhā, e pale ai i ka thromboembolism venous.Hoʻohana ʻia ia no ka mālama ʻana i nā poʻe maʻi me ka angina paʻa ʻole a i ʻole ST-segment elevation myocardial infarction e hana wikiwiki (<120 mau minuke) invasive treatment (PCI) me ka ʻole o ka hōʻike.Hoʻohana ʻia ia no ka mālama ʻana i nā mea maʻi me ka ST-segment elevation myocardial infarction e hoʻohana ana i ka thrombolysis a i ʻole i loaʻa i nā ʻano ʻē aʻe o ka reperfusion therapy.
1)ʻO ka hoʻolaha mau ʻana o ka mākeke ʻo Glaxo e hoʻokomo iā ia i ke kūlana lāʻau lapaʻau ma ke ala lapaʻau ma hope o ke Kuhina Ola, ka hoʻoponopono kumukūʻai o ka National Development and Reform Commission, a me ka ʻinikua olakino o ka Ministry of People's Insurance.
A、ʻAʻole i komo ka huahana i ka ʻinikua olakino aupuni.I ka makahiki 2010, ua komo ka hoʻoponopono ʻinikua olakino i ka ʻinikua olakino kūloko o 16 mau panalāʻau.Aia nā kūʻai i ka pae mua a e hoʻololi mālie i ka mākeke heparin haʻahaʻa-molecular-weight;'inikua 'inikua: Shaanxi, Shanxi, Inner Mongolia, Liaoning, Tibet, Yunnan, Guangdong , Guangxi, Hainan, Jiangsu, Gansu, Fujian, Jiangxi, Henan, Hubei, Beijing.
B、Ke hoʻonui mau nei nā hōʻailona.Loaʻa iā GSK nā hōʻailona 3 i kēia manawa ma ke keʻena.No ka laʻana, ʻae wale ʻia nā hōʻailona no nā stent.ʻAʻole loaʻa nā heparin ʻē aʻe.Hoʻonui ka hoʻohana lapaʻau o nā stents e 30% i kēlā me kēia makahiki.Me ka ʻae ʻia o nā hōʻailona hou, e hoʻonui ʻia nā kūʻai.Ma ke kumumanaʻo, hiki ke mālama ʻia nā maʻi āpau e nā huahana heparin series e kēia huahana.
C、Price pono, ʻo ke kumukūʻai haʻahaʻa o kēia huahana ma ka mākeke US he 132 US kālā kēlā me kēia, ma Kina he 168 yuan, ʻaʻole e hāʻule ke kumu kūʻai kūloko.Inā ʻoe e hoʻopuka aku, he ākea ākea ka mākeke honua;
2) He kiʻekiʻe ka paepae ʻenehana, hoʻohui ʻia ka mea maka i nā ʻanuʻu 75, a ua pau ka patent no 5 mau makahiki (ʻatikala ma 2014).ʻAʻole i ʻae ʻia e nā mea hana ʻē aʻe.Paʻakikī loa ka synthesis.ʻAʻole e hana ʻia ma lalo o 10 mau makahiki.He lōʻihi ka pōʻaiapuni, paʻakikī, a hoʻokomo kālā.kiʻekiʻe.He liʻiliʻi nā mea hoʻokūkū kūloko, a he kiʻekiʻe ko nā mea hoʻokūkū haole.ʻO kā mākou pahuhopu e hoʻemi mau i nā kumukūʻai maka a hoʻololi iā Glaxo i ka hana waiwai.
Ua ʻae ʻia ʻo Hengrui Pharmaceuticals Fondaparinux ma ke ʻano he hoʻohālike mua ma Kina 2018.
ʻO Guangdong Runxing Biotechnology Co., Ltd. he 210 kg o ka fondaparinux sodium advanced intermediate N3, e waiho ʻia ma 2018.
Ua hoʻokumu mua ʻia ʻo Fondaparinux e MYLAN IRELAND.I kēia manawa, Hengrui Pharmaceuticals, Borui Pharmaceuticals, Haisco.
ʻO ke kahua o ka hoʻokō ʻana i nā moeʻuhane o kā mākou limahana!No ke kūkulu ʻana i kahi hui hauʻoli, hui pū a ʻoi aku ka ʻoihana!No ka loaʻa ʻana o ka uku like ʻole o kā mākou mea kūʻai, nā mea hoʻolako, ka hui a me mākou iho no ka MOQ haʻahaʻa no ke kūʻai wela!ʻO ka Hale Hana Mea Kiʻekiʻe Betrixaban Raw Materials CAS 330942-05-7, Heʻoiaʻiʻo mākou a wehe.Ke nānā nei mākou i mua o ka hoʻomaha ʻana a hoʻonohonoho i ka pilina pili pono a lōʻihi.
MOQ haʻahaʻa noKina Lapaʻau Kūwaena a me 330942-05-7, "ʻO ka maikaʻi maikaʻi a me ke kumukūʻai kūpono"ʻo kā mākou mau kumuhanaʻoihana.Inā makemake ʻoe i kā mākou hāʻina a i ʻole he nīnau, e hoʻomanaʻo e hoʻokaʻaʻike mai iā mākou.Manaʻolana mākou e hoʻokumu i nā pilina pili me ʻoe i ka wā e hiki mai ana.