PriceList no ke kiʻekiʻe Antiviral Entecavir Powder CAS 142217-69-4 me ke kumu kūʻai maikaʻi loa.

Hōʻike pū mākou i nā huahana a lawelawe paha a me nā hui hoʻohui mokulele.Loaʻa iā mākou kā mākou ʻāpana hana ponoʻī a me ke keʻena hoʻopukapuka.Hiki iā mākou ke hāʻawi maʻalahi iā ʻoe i nā ʻano mea kūʻai like ʻole e like me kā mākou huahana huahana no PriceList for High Quality Antiviral Entecavir Powder CAS 142217-69-4 me ka Best Price, E hoʻoikaika mau mākou e hoʻonui i kā mākou hui a hāʻawi i nā huahana maikaʻi loa. me nā pae kumu kūʻai ʻino.Mahalo nui ʻia kēlā me kēia nīnau a manaʻo paha.E hoʻomanaʻo e hoʻopaʻa manuahi iā mākou.
Hōʻike pū mākou i nā huahana a lawelawe paha a me nā hui hoʻohui mokulele.Loaʻa iā mākou kā mākou ʻāpana hana ponoʻī a me ke keʻena hoʻopukapuka.Hiki iā mākou ke hāʻawi maʻalahi iā ʻoe me nā ʻano mea kūʻai āpau e like me kā mākou huahana huahana noKina Entecavir a me 142217-69-4, Hoʻokipa maikaʻi mākou i nā mea kūʻai mai loko a me nā ʻāina ʻē e kipa i kā mākou hui a kamaʻilio ʻoihana.Ke koi mau nei kā mākou hui i ke kumu o ka "maikaʻi maikaʻi, ke kumu kūʻai kūpono, ka lawelawe papa mua".Makemake mākou e kūkulu i ka launa pū ʻana me ʻoe no ka wā lōʻihi, aloha a me ka pōmaikaʻi.

Entecavir（SQ 34676;ʻO ka BMS 200475） ka mea hoʻokae HBV koho a maikaʻi.Ma nā pūnaewele HepG2 EC50 waiwai he 3.75 nM.ʻO nā lāʻau anti-hepatitis B hou loa a me ka anti-AIDS laina mua.

Entecavir hopena

ʻO kēia huahana he guanine nucleoside analog, nona ka hopena pale i ka maʻi hepatitis B (HBV) polymerase.Hiki ke phosphorylated i loko o ka triphosphate ikaika, a ʻo ka hapalua o ke ola o ka triphosphate i loko o ke kelepona he 15 mau hola.Ma ka hoʻokūkū ʻana me ka substrate kūlohelohe deoxyguanosine triphosphate o HBV polymerase, hiki i ka entecavir triphosphate ke kāohi i nā hana ʻekolu o ka polymerase viral (reverse transcriptase): (1) HBV polymerase initiation;(2) pregenomic mRNA Ka hoʻokumu ʻana o ke kaula maikaʻi ʻole o ka transcription hoʻohuli;(3) ʻO ka synthesis o ke kaula maikaʻi o HBV DNA.He 0.0012μM ka hoʻopaʻa mau (Ki) o entecavir triphosphate ma HBV DNA polymerase.ʻO Entecavir triphosphate ka hopena hoʻonāwaliwali i ka cell α, β, δ DNA polymerase a me ka mitochondrial γ DNA polymerase, me ka waiwai Ki o 18 a 160 μM.

Nā waiwai kino a me nā kemika o Entecavir

Ka Dute Entecavir

ʻIke hou aku:

ʻO Qu Qiang (PhD i ka lāʻau lapaʻau lāʻau lapaʻau, Keʻena o Pharmacy, Xiangya Hospital, Central South University) a me Wang Ruoguang (Doctor of Medicine, postdoctoral in biology, Changsha Ruoguang Medical Research Center) i kākau pū ʻia: i ka entecavir regimen, hiki ke lawe ʻia ka entecavir no kekahi mau makahiki a i ʻole 10 mau makahiki.ʻOi aku ma mua o nā makahiki.A hiki ke hoʻohana ʻia e nā wahine hāpai, e hōʻike ana i ka palekana maikaʻi.

Ma ka hoʻoholo ʻana mai kēia mau hana lāʻau lapaʻau molecular i ʻike ʻia, hiki i ka Entecavir ke loaʻa i kahi hopena antiviral ākea ākea, ʻaʻole kūpono wale i ka HBV.

Hoʻohana pinepine mākou i ka Entecavir no ka mālama ʻana i nā maʻi hanu viral i loko o ke keʻena, a he mea kupaianaha ka hopena.

I kēia manawa, ma kahi loiloi retrospective o nā mea maʻi ma mua o 500 COVID19 ma Hubei (kahi), hoʻokahi wale nō kanaka i lawe i ka entecavir.ʻO ka manawa kuhikuhi i ka hoʻomaka o Ianuali, a laila ua hoʻopau ʻia ka lāʻau.

ʻOiai ke kākoʻo nei i nā limahana lapaʻau ma Hubei, kekahi mau kauka o ka ʻāina, a i ʻole nā ​​​​hui kiʻekiʻe, ke hoʻohana nei i ka Entecavir e pale i ka COVID19, ʻaʻohe hihia o ka maʻi.ʻO ka poʻe i manaʻo ʻia e lawe i ka entecavir, ʻaʻohe mea i holomua e ʻike ʻia me COVID19.

Nā pilikia patent:

ʻElua mau kaʻina hana, 06 kaʻina a me 89 kaʻina.ʻO ka pau ʻana o ka patent no ke kaʻina hana 06 ʻoi loa (e pau i ka makahiki 2023)!ʻOiai he haʻahaʻa ke kumukūʻai o ke kaʻina hana, ʻoi aku ka maikaʻi o ka maikaʻi, a hiki i nā limahana ke ikaika, ʻōlelo aʻoaʻo pilikino: No nā mea kanu kemika, e hoʻohana i ka hana 06 ʻaʻole e haʻaheo;no nā hui lāʻau lapaʻau, ʻaʻole e lawe i ka puʻuwai a ʻaʻole hoʻi e hoʻoweliweli.

I ka makahiki 2014, ua hoʻokō ʻo Chia Tai Tianqing i nā kūʻai makahiki he 10 biliona yuan ma o ka hilinaʻi ʻana i nā lāʻau lapaʻau e like me entecavir, nona ka entecavir no 20%.

Ma muli o ka ʻae ʻia ʻana o ka entecavir no ka lawe ʻana mai i ka makahiki 2005, ʻoi aku ma mua o 100 mau hui lāʻau lapaʻau kūloko i noi no ke kākau inoa ʻana o ka huahana;i waena o lākou, nā hui hana i ʻae ʻia ʻo Jiangsu Zhengda Tianqing Pharmaceutical (hoʻohālikelike mua), Hainan Zhonghe Pharmaceutical, a me Fujian Guangxi Pharmaceutical Co., Ltd. Shengtang Pharmaceutical, Jiangxi Qingfeng Pharmaceutical, Suzhou Dawnrays Pharmaceutical, Shanghai Qingsong Pharmaceutical, Sichuan Haiscoutical Lukang, Zhejiang Huasheng Biopharmaceutical, Changzhi Sanbao Biochemical.

Pharmaceutical, Anhui Baker Biopharmaceutical, Hunan Concord Pharmaceutical Industry, Beijing Xiehe Pharmaceutical Factory, Beijing Baiao Pharmaceutical, Xinlitai Pharmaceutical, Dongyangguang, etc.;mai ka lā o ka ʻaelike, ua komo kēia huahana i nā kūlana o nā ʻano kaulana kaulana mai 2007.

Hōʻike pū mākou i nā huahana a lawelawe paha a me nā hui hoʻohui mokulele.Loaʻa iā mākou kā mākou ʻāpana hana ponoʻī a me ke keʻena hoʻopukapuka.Hiki iā mākou ke hāʻawi maʻalahi iā ʻoe i nā ʻano mea kūʻai like ʻole e like me kā mākou huahana huahana no PriceList for High Quality Antiviral Entecavir Powder CAS 142217-69-4 me ka Best Price, E hoʻoikaika mau mākou e hoʻonui i kā mākou hui a hāʻawi i nā huahana maikaʻi loa. me nā pae kumu kūʻai ʻino.Mahalo nui ʻia kēlā me kēia nīnau a manaʻo paha.E hoʻomanaʻo e hoʻopaʻa manuahi iā mākou.
PriceList noKina Entecavir a me 142217-69-4, Hoʻokipa maikaʻi mākou i nā mea kūʻai mai loko a me nā ʻāina ʻē e kipa i kā mākou hui a kamaʻilio ʻoihana.Ke koi mau nei kā mākou hui i ke kumu o ka "maikaʻi maikaʻi, ke kumu kūʻai kūpono, ka lawelawe papa mua".Makemake mākou e kūkulu i ka launa pū ʻana me ʻoe no ka wā lōʻihi, aloha a me ka pōmaikaʻi.