Kūʻai kūʻai wela ʻo Ibrutinib Intermediates N-3 CAS 330792-70-6

Me kēia ʻōlelo ma ka noʻonoʻo, ua lilo mākou i waena o nā mea hana ʻenehana hou loa, ʻoi aku ka maikaʻi, a me ka hoʻokūkū kumu kūʻai no Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Ke kakali nei mākou hāʻawi iā ʻoe i kā mākou huahana i ka wā e hiki mai ana, a e ʻike ʻoe i kā mākou ʻōlelo ʻana he kūpono loa a maikaʻi loa ka maikaʻi o kā mākou huahana!
Me kēia huaʻōlelo i ka noʻonoʻo, ua lilo mākou i waena o nā mea hana ʻenehana hou loa, ʻoi aku ka maikaʻi, a me ka hoʻokūkū kumu kūʻai.Kina Ibrutinib N-3 a me nā mea waena, I kēia manawa ua lawe ʻia kā mākou huahana i ka hikina ʻEulopa, ka Middle East, Hikina Hema, ʻApelika a me ʻAmelika Hema a me nā mea ʻē aʻe.Hoʻohanohano mākou i ko mākou poʻo nui o Honesty i ka ʻoihana, ka mea nui i ka lawelawe a e hana mākou i kā mākou mea maikaʻi loa e hāʻawi i kā mākou mea kūʻai aku me nā huahana kiʻekiʻe a me ka lawelawe maikaʻi loa.

ʻO ka waena no ka synthesis o allopurinol.

ʻO ia kekahi o ka 3-amino-4-substituted pyrazole series.Hiki ke hoʻohana ʻia ma ke ʻano he mea waena e synthesize i nā mea hoʻohui lāʻau lapaʻau maikaʻi loa, e like me allopurinol, kekahi o ka pyrazolopyrimidine derivatives series, ka mea hope mai 1963 Mai kona hoʻohana ʻana i ka lāʻau lapaʻau, ʻo ia ka lāʻau nui no ka mālama ʻana i ka gout.I kēia manawa, liʻiliʻi nā ala i ʻike ʻia no ka synthesizing

ʻO ka 3-aminopyrazole-4-carboxamide hemisulfate ma Kina, ma ka hana ʻana i ka malononitrile a me ka triethyl orthoformate e hoʻomākaukau ai i ka ethoxymethylene malononitrile, a laila me ka hopena o ka hydrazine hydrate e hāʻawi mai i ka 3-amino-4-cyanopyrazole, ka mea i hoʻopau hope ʻia me ka acidic concentrated.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis o 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), ka huina o ka hua o ʻO ka synthesis ma kēia ala e pili ana i 60% (helu ʻia e like me ka malononitrile), ʻo kēia ʻano hana ʻekolu mau ʻanuʻu, ʻoi aku ka lōʻihi o nā ʻanuʻu, a ʻo nā reagents i hoʻohana ʻia, e like me malononitrile a me ethoxymethylene malononitrile, ʻoi aku ka ʻona a me ke kumukūʻai.Eia kekahi,ʻo ka 3-aminopyrazole-4 i hoʻomākaukauʻia e kēiaʻano -Formamide hemisulfate he kala paʻakikī e wehe a koi aku i ka hana hou,ʻoi aku ka paʻakikī.

Aia nā hōʻike ma nā palapala haole e hoʻohana ana i ka pyridylamide hydrazone a me ka ethoxymethylene malononitrile ma ke ʻano he kumu waiwai e loaʻa ai ka 3-amino-4-cyanopyrazole ma o ka hoʻohui ʻana a me ka cyclization, a laila e hana me ka sulfuric acid concentrated e loaʻa ai ka pūhui pahuhopu (Reuken G Jones. Reactions of orthoesters with pūhui activemethylene[J] J Am Chem Soc. 1952,74(5) :4889 4891).ʻO nā kumu waiwai nui i hoʻohana ʻia i kēia ʻano he kumukūʻai, ʻaʻole kiʻekiʻe ka hopena o ka hopena, a haʻahaʻa ka loaʻa kālā o ka hana ʻoihana.Paʻakikī paha.

Kūlana hoʻokō:Kūlana ʻoihana
waho:ʻO ka pauka keʻokeʻo a melemele paha

Pūʻolo:25kg / pahu
hōʻike (HPLC) ʻoi aku ka nui a i ʻole like me 98.0%
ʻoi aku ka maʻemaʻe (HPLC) ma mua o 99.5% a i ʻole like.

Ua loaʻa iā JIN DUN MedicalʻO ka hōʻailona ISO a hoʻokō i nā kūlana hana GMP, hoʻohana i nā loea hoʻolaʻa lāʻau kūloko a me nā haole me ka ʻike waiwai e alakaʻi i ka R&D o ka hui.

NA POMAIKAI ANA IA
●Kiʻekiʻe Pressure Catalytic Hydrogenation.ʻO ke kiʻekiʻe o ka Hydrogenolysis Reaction.Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
● Hoʻoponopono hou
●Chiral Resolution
●Heck, Suzuki, Negishi, Sonogashira .Pane ʻo Gignard

Mea lako

Loaʻa i kā mākou Lab nā mea hoʻokolohua like ʻole, e like me: NMR (Bruker 400M) 、HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope…

Pūʻulu R&D

He pūʻulu o nā limahana R&D ʻoihana ʻo Jindun Medical, a hoʻohana i nā loea synthesis lāʻau kūloko a me nā ʻāina ʻē e alakaʻi i ka R&D, e ʻoi aku ka pololei a me ka maikaʻi o kā mākou synthesis.

Ua kōkua mākou i kekahi mau ʻoihana lapaʻau kūloko kiʻekiʻe, e like meHansoh, Hengrui a me HEC Pharm.Maanei e hōʻike mākou i kahi hapa o lākou.

Hana Hana Hoʻokahi:

Ka helu helu: 110351-94-5

Hana Hana Hana ʻelua:

Ka helu helu: 144848-24-8

Hana Hoʻoponopono ʻEkolu:

Ka helu helu: 200636-54-0

1.Hoʻopilikino i nā mea waena hou a i ʻole API.E like me ka mea ma luna o ka hihia kaʻana like, nā mea kūʻai aku i nā koi no nā Intermediates kūikawā a i ʻole API, a ʻaʻole hiki iā lākou ke ʻike i nā huahana e pono ai i ka mākeke, a laila hiki iā mākou ke kōkua iā Customize.

2.Hoʻoponopono Kaʻina no nā Huahana Kahiko.E kōkua kā mākou hui i ka Optimize a hoʻomaikaʻi i ka hana ʻana i ke ala ʻoi aku ka wā kahiko, kiʻekiʻe ke kumu kūʻai, a haʻahaʻa ka hana.Hiki iā mākou ke hāʻawi i nā palapala piha no ka hoʻololi ʻenehana a me ka hoʻomaikaʻi ʻana i ke kaʻina hana, kōkua i ka mea kūʻai aku no ka hana ʻoi aku ka maikaʻi.

Mai nā pahuhopu lāʻau i nā IND, hāʻawi ʻo JIN DUN Medical iā ʻoenā hoʻonā R&D pilikino hoʻokahi.

Ke koi nei ʻo JIN DUN Medical i ka hoʻokumu ʻana i kahi hui me nā moeʻuhane, hana i nā huahana hanohano, meticulous, rigorous, a hele i nā mea a pau e lilo i hoa hilinaʻi a me ka hoaaloha o nā mea kūʻai aku!

Me kēia ʻōlelo ma ka noʻonoʻo, ua lilo mākou i waena o nā mea hana ʻenehana hou loa, ʻoi aku ka maikaʻi, a me ka hoʻokūkū kumu kūʻai no Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Ke kakali nei mākou hāʻawi iā ʻoe i kā mākou huahana i ka wā e hiki mai ana, a e ʻike ʻoe i kā mākou ʻōlelo ʻana he kūpono loa a maikaʻi loa ka maikaʻi o kā mākou huahana!
Kūʻai nuiKina Ibrutinib N-3 a me nā mea waena, I kēia manawa ua lawe ʻia kā mākou huahana i ka hikina ʻEulopa, ka Middle East, Hikina Hema, ʻApelika a me ʻAmelika Hema a me nā mea ʻē aʻe.Hoʻohanohano mākou i ko mākou poʻo nui o Honesty i ka ʻoihana, ka mea nui i ka lawelawe a e hana mākou i kā mākou mea maikaʻi loa e hāʻawi i kā mākou mea kūʻai aku me nā huahana kiʻekiʻe a me ka lawelawe maikaʻi loa.