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5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-hoʻokahi hydrochloride

5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-hoʻokahi hydrochloride

ʻO ka wehewehe pōkole:

CAS no:115473-15-9

Nā waiwai kemika: Prasugrel Intermediates


Huahana Huahana

Huahana Huahana

Hoʻohana

5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-hoʻokahi hydrochloride hoʻohana ʻia ma ke ʻano waena o Prasugrel.

ʻO Prasugrel kahi antiplatelet thiophenopyridine i hoʻomohala ʻia e Eli Lilly a me daiichisankyo, kahi mea hana lāʻau lapaʻau Iapana.He lāʻau mua ia.Hoʻokumu ia i ka molekele ikaika ma hope o ka metabolism ma o ka cytochrome P450 i loko o ke ake a hui pū me ka platelet P2Y12 receptor e hoʻoikaika ikaika e kūʻē i ka platelet aggregation.Ua hōʻike ʻia nā noiʻi maʻi maʻi he 60 mg ka hopena anticoagulant ʻoi aku ka maikaʻi ma mua o 300 mg maʻamau maʻamau a me 600 mg ka nui o ka clopidogrel, hiki ke hōʻemi i ka hopena o ka hōʻeha puʻuwai, ka hahau a me ka make ma muli o ka maʻi puʻuwai e 20%, a he hopena wikiwiki. , maikaʻi curative hopena, maikaʻi lāʻau kū'ē a me ka bioavailability, a haʻahaʻa toxicity.


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